Wei-Chen Chang
Assistant Professor
Department of Chemistry
Dabney Hall 525B
Education
B.S. Chemistry National Taiwan University 2003
Ph.D. Chemistry University of Texas at Austin 2011
Postdoctoral Research Fellow Chemistry Penn State 2015
Area(s) of Expertise
We are elucidating chemical and biological logics of enzymatic transformations. Our interdisciplinary approach involves molecular biology, biological chemistry, organic chemistry, and natural product chemistry.
Publications
- Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis , ACS CATALYSIS (2022)
- Mechanism of Methyldehydrofosmidomycin Maturation: Use Olefination to Enable Chain Elongation , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)
- Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)
- A postreplicative C5-cytosine hypermodification triggered by bacteriophage methyltransferase and hydroxylase , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
- BesC Initiates C-C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)
- Current Understanding toward Isonitrile Group Biosynthesis and Mechanism , CHINESE JOURNAL OF CHEMISTRY (2021)
- Deciphering Pyrrolidine and Olefin Formation Mechanism in Kainic Acid Biosynthesis , ACS CATALYSIS (2021)
- Harnessing the Substrate Promiscuity of Dioxygenase AsqJ and Developing Efficient Chemoenzymatic Synthesis for Quinolones , ACS CATALYSIS (2021)
- Identification of Cyclopropane Formation in the Biosyntheses of Hormaomycins and Belactosins: Sequential Nitration and Cyclopropanation by Metalloenzymes , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
- Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring , BIOCHEMISTRY (2020)