Wei-Chen Chang

Area(s) of Expertise

We are elucidating chemical and biological logics of enzymatic transformations. Our interdisciplinary approach involves molecular biology, biological chemistry, organic chemistry, and natural product chemistry.

Publications

• Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis , ACS CATALYSIS (2022)
• Mechanism of Methyldehydrofosmidomycin Maturation: Use Olefination to Enable Chain Elongation , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)
• Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)
• A postreplicative C5-cytosine hypermodification triggered by bacteriophage methyltransferase and hydroxylase , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
• BesC Initiates C-C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)
• Current Understanding toward Isonitrile Group Biosynthesis and Mechanism , CHINESE JOURNAL OF CHEMISTRY (2021)
• Deciphering Pyrrolidine and Olefin Formation Mechanism in Kainic Acid Biosynthesis , ACS CATALYSIS (2021)
• Harnessing the Substrate Promiscuity of Dioxygenase AsqJ and Developing Efficient Chemoenzymatic Synthesis for Quinolones , ACS CATALYSIS (2021)
• Identification of Cyclopropane Formation in the Biosyntheses of Hormaomycins and Belactosins: Sequential Nitration and Cyclopropanation by Metalloenzymes , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
• Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring , BIOCHEMISTRY (2020)