Wei-Chen Chang

Area(s) of Expertise

We are elucidating chemical and biological logics of enzymatic transformations. Our interdisciplinary approach involves molecular biology, biological chemistry, organic chemistry, and natural product chemistry.

Publications

• Biocatalytic Applications and Mechanistic Insights of Deoxypodophyllotoxin Synthase , Journal of the American Chemical Society (2026)
• Correction to “Regio- and Stereoselective Halogenation by an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase in the Biosynthesis of Halogenated Nucleosides” , Journal of the American Chemical Society (2026)
• Experimental and Computational Elucidation of C( sp 3)–H Fluorination Barriers in an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase , Journal of the American Chemical Society (2026)
• Metacycloprodigiosin produced by a high-yield Streptomyces spectabilis restores colistin susceptibility in resistant Gram-negative pathogens , Organic & Biomolecular Chemistry (2026)
• Recent discoveries in mono- and dinuclear nonheme iron enzymes: Emerging mechanisms and catalytic strategies , Archives of Biochemistry and Biophysics (2026)
• Thermodynamic and Mechanistic Aspects of Small-Ring Formation Mediated by Nonheme-Iron and 2-Oxoglutarate Dependent Enzymes , ACS Bio & Med Chem Au (2026)
• An Alternative Mechanism for C–C Desaturation Underscores a Dual-Controlled Mechanism for the Fate of Radical Intermediate in Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenase DfmD , Journal of the American Chemical Society (2025)
• Beyond the β–α–β Fold: Characterization of a SnoaL Domain in the Tautomerase Superfamily , Biochemistry (2025)
• Bioinformatic, structural, and biochemical analysis leads to the discovery of novel isonitrilases and decodes their substrate selectivity , RSC Chemical Biology (2025)
• Comparison of a Nonheme Iron Cyclopropanase with a Homologous Hydroxylase Reveals Mechanistic Features Associated with Distinct Reaction Outcomes , Journal of the American Chemical Society (2025)