Wei-Chen Chang
Education
B.S. Chemistry National Taiwan University 2003
Ph.D. Chemistry University of Texas at Austin 2011
Postdoctoral Research Fellow Chemistry Penn State 2015
Area(s) of Expertise
We are elucidating chemical and biological logics of enzymatic transformations. Our interdisciplinary approach involves molecular biology, biological chemistry, organic chemistry, and natural product chemistry.
Publications
- Poly-γ-glutamylation of biomolecules , NATURE COMMUNICATIONS (2024)
- Variation in Biosynthesis and Metal-Binding Properties of Isonitrile-Containing Peptides Produced by Mycobacteria versus Streptomyces , ACS CATALYSIS (2024)
- A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)
- An S=1 Iron(IV) Intermediate Revealed in a Non-Heme Iron Enzyme-Catalyzed Oxidative C-S Bond Formation , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)
- Current understanding of lignan biosynthesis , ARKIVOC (2023)
- Excision of a Protein-Derived Amine for p-Aminobenzoate Assembly by the Self-Sacrificial Heterobimetallic Protein CADD , BIOCHEMISTRY (2023)
- Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)
- Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron Enzymes , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)
- Repurposing Iron- and 2-Oxoglutarate-Dependent Oxygenases to Catalyze Olefin Hydration , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)
- Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis , ACS CATALYSIS (2022)