Wei-Chen Chang

Area(s) of Expertise

We are elucidating chemical and biological logics of enzymatic transformations. Our interdisciplinary approach involves molecular biology, biological chemistry, organic chemistry, and natural product chemistry.

Publications

• An Alternative Mechanism for C-C Desaturation Underscores a Dual-Controlled Mechanism for the Fate of Radical Intermediate in Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenase DfmD , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2025)
• Beyond the β-α-β Fold: Characterization of a SnoaL Domain in the Tautomerase Superfamily , BIOCHEMISTRY (2025)
• Comparison of a Nonheme Iron Cyclopropanase with a Homologous Hydroxylase Reveals Mechanistic Features Associated with Distinct Reaction Outcomes , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2025)
• Discovery of Noncanonical Iron and 2-Oxoglutarate Dependent Enzymes Involved in C-C and C-N Bond Formation in Biosynthetic Pathways , ACS BIO & MED CHEM AU (2025)
• A survey of C-C bond formation strategies and mechanism deployed by iron-containing enzymes in natural products , TETRAHEDRON (2024)
• Bioinformatic, structural, and biochemical analysis leads to the discovery of novel isonitrilases and decodes their substrate selectivity , RSC CHEMICAL BIOLOGY (2024)
• New Frontiers in Nonheme Enzymatic Oxyferryl Species , CHEMBIOCHEM (2024)
• Optimized Substrate Positioning Enables Switches in the C-H Cleavage Site and Reaction Outcome in the Hydroxylation-Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2024)
• Poly-γ-glutamylation of biomolecules , NATURE COMMUNICATIONS (2024)
• Variation in Biosynthesis and Metal-Binding Properties of Isonitrile-Containing Peptides Produced by Mycobacteria versus Streptomyces , ACS CATALYSIS (2024)