Wei-Chen Chang ☑️

Area(s) of Expertise

We are elucidating chemical and biological logics of enzymatic transformations. Our interdisciplinary approach involves molecular biology, biological chemistry, organic chemistry, and natural product chemistry.

Publications

• An Alternative Mechanism for C-C Desaturation Underscores a Dual-Controlled Mechanism for the Fate of Radical Intermediate in Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenase DfmD , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2025)
• Beyond the β-α-β Fold: Characterization of a SnoaL Domain in the Tautomerase Superfamily , BIOCHEMISTRY (2025)
• Comparison of a Nonheme Iron Cyclopropanase with a Homologous Hydroxylase Reveals Mechanistic Features Associated with Distinct Reaction Outcomes , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2025)
• Discovery of Noncanonical Iron and 2-Oxoglutarate Dependent Enzymes Involved in C-C and C-N Bond Formation in Biosynthetic Pathways , ACS BIO & MED CHEM AU (2025)
• Multiple Catalytic Branch Points in the Mechanism of Pyrrolidine Formation During Kainoid Biosynthesis Leads to Diverse Reaction Outcomes , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2025)
• Provision of a Redox Donor to Oxy-Ferrous PrnB Is Required for Pyrrolnitrin Synthesis , BIOCHEMISTRY (2025)
• Studies of Isonitrile Synthases Help Elucidate the Mechanism of Isonitrile Installation , ACS CATALYSIS (2025)
• A survey of C-C bond formation strategies and mechanism deployed by iron-containing enzymes in natural products , TETRAHEDRON (2024)
• Bioinformatic, structural, and biochemical analysis leads to the discovery of novel isonitrilases and decodes their substrate selectivity , RSC CHEMICAL BIOLOGY (2024)
• New Frontiers in Nonheme Enzymatic Oxyferryl Species , CHEMBIOCHEM (2024)