Wei-Chen Chang
Assistant Professor
He/Him/His
Department of Chemistry
Dabney Hall 525B
Education
B.S. Chemistry National Taiwan University 2003
Ph.D. Chemistry University of Texas at Austin 2011
Postdoctoral Research Fellow Chemistry Penn State 2015
Area(s) of Expertise
We are elucidating chemical and biological logics of enzymatic transformations. Our interdisciplinary approach involves molecular biology, biological chemistry, organic chemistry, and natural product chemistry.
Publications
- Bioinformatic, structural, and biochemical analysis leads to the discovery of novel isonitrilases and decodes their substrate selectivity , RSC CHEMICAL BIOLOGY (2024)
- Comparison of a Nonheme Iron Cyclopropanase with a Homologous Hydroxylase Reveals Mechanistic Features Associated with Distinct Reaction Outcomes , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2025)
- Discovery of Noncanonical Iron and 2-Oxoglutarate Dependent Enzymes Involved in C-C and C-N Bond Formation in Biosynthetic Pathways , ACS BIO & MED CHEM AU (2025)
- A survey of C-C bond formation strategies and mechanism deployed by iron-containing enzymes in natural products , TETRAHEDRON (2024)
- New Frontiers in Nonheme Enzymatic Oxyferryl Species , CHEMBIOCHEM (2024)
- Optimized Substrate Positioning Enables Switches in the C-H Cleavage Site and Reaction Outcome in the Hydroxylation-Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2024)
- Poly-γ-glutamylation of biomolecules , NATURE COMMUNICATIONS (2024)
- Variation in Biosynthesis and Metal-Binding Properties of Isonitrile-Containing Peptides Produced by Mycobacteria versus Streptomyces , ACS CATALYSIS (2024)
- A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)
- An S=1 Iron(IV) Intermediate Revealed in a Non-Heme Iron Enzyme-Catalyzed Oxidative C-S Bond Formation , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)