Hosni Hassan

Bio

*Not currently taking new graduate students*

Dr. Hosni Hassan earned his Ph.D. in microbiology from the University of California, Davis in 1967. From 1968-1972, he served as an Assistant Professor of Food Microbiology and Biochemistry at the university of Alexandria, Egypt. He was a Research fellow in Biochemistry at Duke University, Durham, NC (1976-1978), and in 1979 he became an Associate Professor of Microbiology at McGill University Medical School, Montreal, Canada. In 1980, he accepted the position of Associate professor of Food Science and Microbiology in the Food Science Department at NC State, and in 1984 he was promoted to Full Professor. He became a Professor of Biochemistry (1990-1993), and served as the Head of the Microbiology Department at NC State (1993-2004) and concurrently served as an Interim Head of Toxicology (2000-2001). In 2013, he joined the Prestage Department of Poultry Science.  Dr. Hassan’s research is focused on oxidative stress and regulation of the antioxidant enzymes (superoxide Dismutases and Hydroperoxidases) in E. coli and Salmonella. His current research aims to develop novel Salmonella control strategies, including the development of new vaccine(s) for poultry and other animals, isolation/ characterization of poultry-specific probiotic lactobacilli, and preventing the transfer of antibiotic resistance traits among members of the gut microbiota.

Area(s) of Expertise

Dr. Hassan’s research focuses on applying microbial physiology, genetics and molecular biology to food safety, to protect public health.
Research interests include

- microbiology and food safety
- poultry microbiome and metabolome
- developing patented salmonella vaccines
- isolation/application of species-specific probiotics
- developing best practices to eliminate human salmonellosis

Publications

• Complete genome sequences of Lactobacillus acidophilus strain P42 and Limosilactobacillus reuteri strain P43 isolated from chicken cecum , MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2024)
• In ovo feeding of probiotic lactobacilli differentially alters expression of genes involved in the development and immunological maturation of bursa of Fabricius in pre-hatched chicks , POULTRY SCIENCE (2023)
• Modulation of functional activity of heat-stressed chicken macrophages by poultry-derived probiotic lactobacilli , CANADIAN JOURNAL OF ANIMAL SCIENCE (2022)
• On 'Intracellular production of superoxide radical and of hydrogen peroxide by redox active compounds' by H. Moustafa Hassan, Irwin Fridovich , Archives of Biochemistry and Biophysics (2022)
• Role of the Mn-Catalase in Aerobic Growth of Lactobacillus plantarum ATCC 14431 , Applied Microbiology (2021)
• Attenuated Salmonella enterica Serovar Typhimurium, Strain NC983, Is Immunogenic, and Protective against Virulent Typhimurium Challenges in Mice , VACCINES (2020)
• Complete Genome Sequences of Lactobacillus Strains C25 and P38, Isolated from Chicken Cecum , Microbiology Resource Announcements (2020)
• Complete Genome Sequences of Six Lactobacilli Isolated from American Quarter Horses , MICROBIOLOGY RESOURCE ANNOUNCEMENTS (2020)
• A comparison of sequencing platforms and bioinformatics pipelines for compositional analysis of the gut microbiome , BMC MICROBIOLOGY (2017)
• An Attenuated Salmonella enterica Serovar Typhimurium Strain and Galacto-Oligosaccharides Accelerate Clearance of Salmonella Infections in Poultry through Modifications to the Gut Microbiome , Applied and Environmental Microbiology (2017)