Rodolphe Barrangou ☑️
Todd R. Klaenhammer Distinguished Professor
Department of Food, Bioprocessing and Nutrition Sciences
Schaub Food Science Building, Room 339B
Bio
Area(s) of Expertise
Our laboratory focuses on the biology and genetics of CRISPR-Cas immune systems in bacteria. Using microbiology, molecular biology and genomics approaches, we investigate the use of CRISPR-Cas systems for three types of applications:
- The exploitation of CRISPR spacer hypervariability for genotyping and phylogenetic studies of beneficial and pathogenic bacteria
- Leveraging CRISPR-mediated interference for building up phage resistance in probiotic strains and starter cultures used in food manufacturing
- Harnessing of Cas9-mediated, re-programmable dsDNA cleavage for genome editing in bacteria
These activities provide insights into the genetic and molecular processes that drive CRISPR-mediated adaptive immunity in bacteria and generate novel tools for the manipulation of industrially relevant organisms for food and biotechnological applications.
Teaching Activities
- Introduction to Biopharmaceutical Sciences (BBS 201)
- MR Supervised Research (FS 693)
- Fermentation Microbiology (FS 725)
- DR Supervised Research (FS 893)
Education
B.S. Business Administration University of Wisconsin – Madison 2011
M.S. Functional Genomics North Carolina State University 2004
M.S. Food Science North Carolina State University 2000
Ph.D. Biological Engineering University of Technology in Compiegne 2000
MBA Life Sciences University of Paris V – Rene Descartes 1996
Publications
- AI and SynBio Meet CRISPR Heralding a New Genome Editing Era , The CRISPR Journal (2024)
- Characterization of Ligilactobacillus salivarius CRISPR-Cas systems , MSPHERE (2024)
- Five Years of Progress in CRISPR Clinical Trials (2019-2024) , CRISPR JOURNAL (2024)
- Surveying the State of CRISPR and Gene Editing , CRISPR JOURNAL (2024)
- Lactobacillus acidophilus Expressing Murine Rotavirus VP8 and Mucosal Adjuvants Induce Virus-Specific Immune Responses , VACCINES (2023)
- Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut , NATURE MICROBIOLOGY (2023)
- CRISPR Technology and its Many Applications with Select Examples Related to Animal Agriculture , JOURNAL OF ANIMAL SCIENCE (2023)
- CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes , NUCLEIC ACIDS RESEARCH (2023)
- Genome-Wide Comparative Analysis of Lactiplantibacillus pentosus Isolates Autochthonous to Cucumber Fermentation Reveals Subclades of Divergent Ancestry , FOODS (2023)
- Impact of Pomegranate on Probiotic Growth, Viability, Transcriptome and Metabolism , MICROORGANISMS (2023)