José Bruno-Bárcena

Area(s) of Expertise

Industrial Microbiology of high-value products including Microbial Communities, Probiotics, Prebiotics, Enzymes, Chemicals, and Biofuels
There is a critical need for the systematic identification and testing of dynamic community behavior as well as gene modulated states participating in the enhancement of cellular stress resistance of cultures. In our laboratory we use the new era of bioprocessing and genomic tools that make it possible control physiological states and to identify point mutations, insertions, deletions and/or translocations that have occurred in offspring strains following defined selection processes. In the near future, this comparative physiological/genetic approach will provide valuable insights for identifying gene combinations and new biochemical pathways, both playing a role in community microbial cross-feeding metabolism. This information may be applied to further improve microbial production or to understand dysbiosis by using strategic strain combinations and/

Publications

• Gut Microbial Dipeptidyl Peptidase-4 and Associated Prolyl Tripeptidyl Peptidases: A Novel Classification and Response to Inhibitors , (2025)
• Prebiotic β (1–4) galacto-oligosaccharides strengthen intestinal barrier integrity via mucus production and modulation of tight junction genes , Food Bioscience (2025)
• Non-stochastic reassembly of a metabolically cohesive gut consortium shaped by N-acetyl-lactosamine-enriched fibers , Gut Microbes (2024)
• Structural analysis and functional evaluation of the disordered ß–hexosyltransferase region from Hamamotoa (Sporobolomyces) singularis , Frontiers in Bioengineering and Biotechnology (2023)
• Application of raw industrial sweetpotato hydrolysates for butanol production by Clostridium beijerinckii NCIMB 8052 , Biomass Conversion and Biorefinery (2022)
• Randomized placebo-controlled trial of feline-origin Enterococcus hirae probiotic effects on preventative health and fecal microbiota composition of fostered shelter kittens , Frontiers in Veterinary Science (2022)
• Correction to: The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut , Microbiome (2021)
• Safety and Modulatory Effects of Humanized Galacto-Oligosaccharides on the Gut Microbiome , Frontiers in Nutrition (2021)
• The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut , Microbiome (2021)
• Accelerated Biodegradation of the Agrochemical Ametoctradin by Soil-Derived Microbial Consortia , Frontiers in Microbiology (2020)