Matt Koci

Bio

Dr. Matthew Koci earned his Bachelor’s of Science from Virginia Tech and his Master’s of Science and Ph.D. from the University of Georgia. Dr. Koci’s research focuses on understanding how bacteria and viruses cause disease; and how the host responds to those threats. Much of his current work is centered around gut health and deciphering how the intestinal microbiome communicates with the mucosal immune system. The ultimate goal of this work is to develop novel ways of preventing disease and promoting health, welfare and performance.

Area(s) of Expertise

Dr. Koci is a virologist and immunologist and his research, teaching and outreach program is focused on host-pathogen interactions and understanding how the gut immune system tells friend from foe.

Dr. Koci's laboratory works to understand the immune mechanisms which allow an animal to recognize, respond, eliminate and develop resistance to pathogens. The lab's approach involves understanding both cellular and molecular aspects of the host response. Currently there are three primary research projects in the laboratory: 1) understanding the key innate immune responses involved in pathogenesis and disease resolution of astrovirus induced gastroenteritis, a major cause of diarrhea in turkey poults and humans, 2) understanding how genetic polymorphisms in innate immune response genes affect resistance and susceptibility to infection, and 3) understanding how changes in the intestinal microflora affects gut physiology, mucosal immunity and, ultimately, the overall health of the animal.

Publications

• Fluoroquinolone-resistant Campylobacter in backyard and commercial broiler production systems in the United States , JAC-ANTIMICROBIAL RESISTANCE (2024)
• Pleurotus eryngii polysaccharides alleviate aflatoxin B 1-induced liver inflammation in ducks involving in remodeling gut microbiota and regulating SCFAs transport via the gut-liver axis , INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)
• Rutin, a natural flavonoid glycoside, ameliorates zearalenone induced liver inflammation via inhibiting lipopolysaccharide gut leakage and NF-κB signaling pathway in mice , FOOD AND CHEMICAL TOXICOLOGY (2024)
• Widespread prevalence of plasmid-mediated bla_CTX-M type extended-spectrum beta-lactamase Escherichia coli in backyard broiler production systems in the United States , PLOS ONE (2024)
• Beyond Better Medicines , (2023)
• Chlorogenic Acid Alleviated AFB1-Induced Hepatotoxicity by Regulating Mitochondrial Function, Activating Nrf2/HO-1, and Inhibiting Noncanonical NF-κB Signaling Pathway , ANTIOXIDANTS (2023)
• NF-KB activation enhances STING signaling by altering microtubule-mediated STING trafficking , CELL REPORTS (2023)
• Science Communication Training Imparts Confidence and Influences Public Engagement Activity , JOURNAL OF MICROBIOLOGY & BIOLOGY EDUCATION (2023)
• COVID-19: The Beginning of The Beginning , (2022)
• LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity , CELL REPORTS (2022)